ea0081p455 | Reproductive and Developmental Endocrinology | ECE2022
Lazzaretti Clara
, Casadei Garofani Beatrice
, Paradiso Elia
, D'Alessandro Sara
, Sperduti Samantha
, Roy Neena
, Mascolo Elisa
, Baschieri Lara
, Anzivino Claudia
, Simoni Manuela
, Casarini Livio
Introduction: Follicle-stimulating hormone (FSH) is a glycoprotein that support reproduction by regulating ovarian follicular growth and development. Recent studies demonstrated that proliferative signals mediating folliculogenesis are mediated by the G protein-coupled estrogen receptor (GPER) expressed in ovarian tissues throughout the follicular phase. In granulosa cells, GPER forms heteromers with FSHR, reprogramming cAMP-induced death signals to AKT-dependent, anti-apoptot...